Renal protection in immunoglobulin-A nephropathy.

Sir, I applaud the timely reminder by Nagy et al. [1] that good control of hypertension can do much to ameliorate the course of immunoglobulin-A nephropathy. There are some good antiproliferative agents coming along. Only I wish to point out that we have forgotten [2] the potential of anti-thromboxanes [3], which will surely be synergistic to angiotensin-converting enzyme or angiotensin-receptor blocker inhibitors. After all, thromboxane A2 partly mediates the action of angiotensin II [4].